Posts Tagged ‘Stem’

If you’ve been wondering about what on earth pluripotent stem cells are, then this is the article for you. We’ll look at what they are, what they do and most importantly why they are not the answer to all our health issues. By the end, you’ll have a great understanding and will know all about them.

First, let’s look at what they are. Pluripotent stem cells are found in relatively small numbers in the body in various tissues and umbilical cord blood. Much of the research has been to identify their differentiation potential and we have even seen procedures whereby umbilical cord stem cells have been re-injected into patients. They do not attract the same controversy surrounding embryonic stem cells, and because they are derived from a born human being, are also classified as adult stem cells.

Next, let’s look at what they do. For most pluripotent adult stem cells, their ability to regenerate is limited to the tissues they are taken from. For example, stem cells taken from the skin will only become skin cells. Injecting them into the liver, will not result in new liver cells. Researchers are trying to find a way to change these pluripotent adult stem cells to become any cell of the body.

Finally, let’s look at why pluripotent stem cells are not the answer to all our health issues. As we have already seen, PSC taken from skin for example, cannot become new cells of the liver. This won’t help people with cardiovascular disease or degenerative conditions such as Parkinson’s. The answer lies in another type of adult stem cells — the ones from our bone marrow.

For years, we’ve used these successfully to treat leukemia and blood/bone cancers by transplanting them into patients. The newest research however, indicates there are some 150 million adult stem cells in our bone marrow and that as stem cells that can become any type of tissue, they represent the renewal system of the body.

So there you have it, everything you wanted to know about pluripotent stem cells. We’ve looked at what they, what they do and finally why they are not the answer to our health problems. All the latest research points to adult stem cells from our own bone marrow being the natural renewal system of our bodies, so all we need to do is get more of them to release into our bloodstream.

 

Learn How to Unleash the Awesome Power of Your Own Stem Cells at MyStemCellPower.com

Will Stem Cell Research Lead To A Baldness Cure?

In this video I cover the super important potential baldness cure.

http://www.medicalnewstoday.com/articles/271898.php

Please watch this new documentary showing the amazing results from cord blood stem cells in our son’s life. www.KensJourneyToRecovery.Blogspot.com. The clinic we used was the top clinic in the world, the Stem Cell Institute in Panama City, Panama. **note. The footage at the beginning of the film and throughout Ken was 8 YEARS old, not 2, like mentioned in news articles.
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This stem cells animation explains about stem cell therapy.
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Stem cells are biological cells found in all multicellular organisms, that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce more stem cells. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells (these are called pluripotent cells), but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.

There are three accessible sources of autologous adult stem cells in humans:

Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically the femur or iliac crest),
Adipose tissue (lipid cells), which requires extraction by liposuction, and
Blood, which requires extraction through pheresis, wherein blood is drawn from the donor (similar to a blood donation), passed through a machine that extracts the stem cells and returns other portions of the blood to the donor.

Stem cells can also be taken from umbilical cord blood just after birth. Of all stem cell types, autologous harvesting involves the least risk. By definition, autologous cells are obtained from one’s own body, just as one may bank his or her own blood for elective surgical procedures.

Highly plastic adult stem cells are routinely used in medical therapies, for example in bone marrow transplantation. Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies.[1] Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s.[2][3] Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page Animation source: Learn genetics, University of UTAH
Link- http://learn.genetics.utah.edu/content/tech/stemcells/scintro/
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Enliven: Journal of Stem Cell Research & Regenerative Medicine is an Open access, peer reviewed international journal and it aims to publish different types of articles on emerging developments and supports current and upcoming research in the field of stem cell biology. This journal also allows articles on developmental biology and regenerative medicine.
This journal will support the budding scientists, scholars, academicians, researchers, and students by providing Open access platform for publishing their work.
This journal will follow the peer review policies and will bode Open access in having quality research output.
This journal combines the innovative scientific ideas and ways in stem cell biology, developmental biology, regenerative medicine and all other related disciplines to have an innovative output.

You may have heard of stem cells before, but there is a lot of mystery about what they actually … do. Why is this such a promising new field?

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Sources:
Bone marrow transplant:
http://www.cancer.net/navigating-cancer-care/how-cancer-treated/bone-marrowstem-cell-transplantation/what-stem-cellbone-marrow-transplantation
http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm
Gene Expression:
http://www.nature.com/scitable/topicpage/gene-expression-14121669
http://www.pa.msu.edu/sciencet/ask_st/060293.html
Stem Cells:
http://stemcells.nih.gov/info/basics/pages/basics3.aspx
http://www.medicalnewstoday.com/info/stem_cell/

If you’ve always wondered about how bone marrow creates adult stem cells, then this is the article for you. We’ll look at the bone structure, the bone marrow and finally how adult stem cells are released. By the end, you’ll have a great understanding of just what happens with adult stem cells and our bone marrow.

First, let’s look at the bone structure. Many people believe the bones have very little blood circulation, but this is incorrect. There is voluminous blood flow and our bones contain both compact and spongy structure. The compact bone gives strength, while the spongy bone contains the marrow.

Next, let’s look at the bone marrow itself. Ask anyone what color bone marrow is and they’ll most likely say yellow. This is not completely true. Children have only red bone marrow, it’s only as we age that the red marrow is displaced by fat storing yellow marrow. Adults still have red marrow in the ribs, vertebrae, pelvis and skull. This red marrow is where our adult stem cells are located and as we get less red marrow as we age, this explains the drop in stem cell production. It is estimated however, that our bone marrow contains around 150 million adult stem cells.

Finally, let’s look at how bone marrow stem cells are released. Generally speaking in the body, cells divide through symmetrical division whereby a cell creates 2 identical cells which contain the original DNA. With the bone marrow however, asymmetrical division occurs. This is where a cell creates 2 different cells — 1 with copies of the DNA and the other with the original DNA. The copied DNA stem cell leaves the bone marrow, while the original DNA stem cell remains behind. This process is known as immortal strand hypothesis and ensures the number of adult stem cells always remains constant in the bone marrow.

So there you have it, a short guide explaining how the bone marrow creates adult stem cells. We’ve looked at bone structure, the bone marrow and finally how adult stem cells are released from the bone marrow. The most important things to remember are that this process is natural but is reduced with age and that supporting the release of adult stem cells from the bone marrow will not reduce their numbers.

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Stem cells are found in all multi-cellular organisms. Basically two types of stem cells are found: These are the pluripotent and multipotent. Stem cell growth, in general, depending on their prototype has the capability to generate different types of cells in the body. And the growth of these cell stems may function like a natural replenishing system for the body promoting repair and nurturing other cells during the rest of life span.

 

When a stem cell gets divided, each of the new cells is termed as the daughter cell and in course of time each of the daughter cells becomes either a stem cell or turn into other specific type of cells with specific function. For example, brain cell, red blood cell or a muscle cell.

 

The discovery of stem cells and their growth potential has unveiled its scope in multiple areas of health and medical research. The study of the stem cells has revealed the mystery of the creation of the specialized cells out of these mother cells. The analysis of this cell division process on the other hand have been able to explain our inherent cell division process, its pattern, and correlated contribution of cell division in our development and over-all growth of the body.

 

The insight on the growth potential of stem cells has opened a new avenue for medical treatments. Doctors collect highly plastic adult stem cells from different sources such as the umbilical cord blood, bone marrow and such for different medical therapies. Embryonic cell lines and autologous embryonic stem cells can be regenerated through therapeutic cloning process and the possibility of these generating processes is expected to unhinge new possibilities of medical treatments and repair processes.

 

Stem cells are now counted as a potential resource for multiple medical benefits. The stem cells have also opened a new possibility for recovery in the area of medical organ transplantation. For instance, donated organs and tissues are often used to replace the diseased and destroyed organs. But there are several instances where the unavailability of fresh organs makes the transplant uncertain and complicated.  According to researchers, meticulous use of the Pluripotent stem cells can solve this kind of situational intricacy by regeneration of new tissues and cells. This transplantation can treat countless incurable diseases like the injuries to the spinal cord, heart diseases, arthritis, diabetes, amyotrophic lateral sclerosis, Parkinson’s disease, and many more.

 

It is expected that while working on and analyzing the stem cell growth closely, scientists in near future, may be able to replace damaged organs or consider the addition of new genes to the stem cells. These may prove to be beneficial to implant necessary immunity power required for the treatment of a disease by developing the auto immune power of the patient.

 

Article by Jenny at Inter-Dev SEO Company on behalf of Drug delivery systems

Stem cell treatment and research towards curing illness–from multiple sclerosis to spinal injury–is detailed by Dr. Neil Riordan. The American medical industry, obstructions to research in the states, misconceptions about stem cells, and the details about the treatment process are explained–and we look at video of patient recovery and speculate at what the future could spell for stem cell treatment and research in this Lip News interview, hosted by Elliot Hill.

GUEST BIO:
Dr. Neil Riordan is the founder and Chairman of Medistem Panama, a leading stem cell laboratory and research facility – located in Panama City. His institute is at the forefront of research of the effects of adult stem cells on the course of several chronic diseases. Dr. Riordan has more than 60 scientific articles in international peer-reviewed journals. In the stem cell arena, he and his colleagues have published more than 20 articles on Multiple Sclerosis, Spinal Cord Injury, Heart Failure, Rheumatoid Arthritis.

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EPISODE BREAKDOWN:
00:01 Welcome to The Lip News Interviews.
00:05 Introducing Dr. Neil Riordan, Founder and chairman of Medistem Panama.
00:55 The unique properties of stem cells.
05:15 Unique applications of stem cells.
06:40 Video of stem cell patient with Multiple Sclerosis.
09:30 What is the treatment process like?
10:50 Disputing skepticism surrounding stem cell treatment.
12:25 Are some patients slow to respond or non responsive to stem cell treatment?
14:15 Roadblocks encountered in the United States.
16:30 Desire for profit slowing the advancement of healthcare.
18:05 Video of stem cell patient recovering from spinal injury.
20:45 The future of stem cell research and treatment for Medistem Panama.
21:45 Thank you and goodbye

http://articles.mercola.com/sites/articles/archive/2016/05/29/platelet-stem-cell-therapy.aspx?utm_source=youtube&utm_medium=video&utm_campaign=content_interview Natural health expert and Mercola.com founder Dr. Joseph Mercola interviews James Leiber, a D.O., about a number of different stem cell products and techniques he uses in his practice.
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The third instalment of RTÉ’s documentary series, ‘Science Friction’ where science and society collide, explores one of the most controversial issues in the history of science: the human embryo and its use in the ground-breaking field of stem cell research.

In this episode, presenter Liz Bonnin embarks on a journey to meet the different people, both within and outside the science community, whose lives are touched by the controversy surrounding the embryo. Liz talks to 22-year-old Geoff Harte, who was left paralysed after breaking his neck in a school rugby match, and now believes that stem cells may one day help him to walk again.

We also hear from Stephen Sullivan, a Harvard based Irish scientist who uses frozen embryos left over as a result of IVF treatment, as a source of stem cells for his groundbreaking research. On the flip side of the coin, Martin Clynes, a scientist at Dublin City University, explains why he passionately believes that research which destroys human embryos is morally unacceptable.

And finally, Liz meets Lisa O’Callaghan who, after giving birth to a daughter thanks to IVF treatment, now finds herself with frozen embryos of her own and confusion over what will become of them. O’Callaghan is not alone; this is an issue particularly relevant to Ireland, where the status of the embryo is mired in ambiguity and embryonic stem cell research remains a no-go area for scientists.

Stem cell research is one of the most exciting branches of modern medical science. Stem cells have the ability to transform themselves into any of the over 200 different types of cells found in the human body. Stem cells have been hailed by many scientists as the source of potential treatments for currently incurable conditions such as Parkinson’s Disease, Multiple Sclerosis, and spinal injury.

However it’s not a straight-forward ‘good news’ story because according to a large body of scientists, the best source of stem cells is currently the human embryo and in order to remove the stem cells, the embryo must be destroyed.

The controversy revolves around people’s perception of the embryo. To some, it is the very early stage in the life of a human being and must be afforded the same rights as a fully developed person. But, to others, it is a collection of cells which, while having the potential to become a human being, can justifiably be used instead to treat terrible diseases.

In this compelling documentary, Bonnin confronts the fact that, sooner or later, the Irish public will have to make a decision on how we view the human embryo.
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Our body’s tissue is subject to a continuous regeneration process. The ability of adult stem cells to self-renew and to generate fast proliferating progenitor cells is an absolute prerequisite for tissue regeneration. Because the skin is an exceptionally highly regenerative tissue, the skin stem cell population represents the most important target for anti-ageing treatments. But, regardless of the regenerative power of stem cells, our skin loses its elasticity and firmness and forms wrinkles as we age. The regenerative potential of the stem cells apparently does not last forever; they too age. Ingredients, specifically designed to delay the depletion of their regeneration capacity, are a most promising solution to keeping skin looking youthful longer.

We are in need of novel in vitro models to test stem cell claims
Meanwhile a lot of research is being done on the mechanism of epidermal regeneration by stem cells embedded in specific niches located at the basal layer of the epidermis. In vitro test systems using epidermal stem cells have been established which allow claims for epidermal stem cell actives. Also dermal stem cells could be targeted by cosmetic ingredients. Fibroblasts, the prominent cell type in the dermis, are responsible for the continuous production of collagen and elastin. These proteins form the so called extracellular matrix, a three dimensional structure that confer elasticity and firmness to the skin. Age-related reduction in the formation of the extracellular matrix and environmental stress factors that lead to the breakdown of the existing matrix are key elements in the skin ageing process and directly involved in wrinkle formation. Controlling the regenerative potential of dermal stem cells would make it possible to correct loss of skin firmness and elasticity and to prevent wrinkles.

A novel cell culture assay to address dermal stem cell activity
Details of the dermal stem cell niche and marker expression remained scarce. But recently, a research group at the University of Toronto showed that the dermal papilla is a niche for dermal progenitor/stem cells. These cells were found to self-renew, to induce the formation of hair follicles and to migrate into the inter-follicular dermis where they proliferated and differentiated to fibroblast cells, able to regenerate the extracellular matrix. Other characteristics of these cells were the expression of a specific marker gene Sox2 and the tendency to grow in colonies in the form of spheres. Mibelle Biochemistry is now working on a human dermal papilla cell line as a new test system for the evaluation of active ingredients for stem cell vitalization potential. The established cell line was found to effectively form sphere-like colonies and the cells in those spheres were found to be uniformly Sox2-labelled, thus representing real dermal stem cells.

Working with human dermal stem cells
Progenitor cells isolated from the dermal papilla of excised human hair follicles could be maintained as a monolayer culture for at least 11 passages. At both passage 3 and passage 11 cells transferred into hanging drops formed 3D spheres, demonstrating that this important characteristic of progenitor cells was retained even after longer-term cultivation. In addition, immunofluorescent labelling of whole mount spheres showed positive staining for the Sox2, a proposed dermal stem cell marker. When cells dissociated from primary spheres were seeded back into classical cell culture dishes used for routine monolayer culture, numerous secondary spheres were formed. This indicates that once cells have formed primary spheres, they seem to retain a memory of the 3D progenitor phenotype, and preferentially re-form spheres where normally monolayer cultures would be expected to form.

Conclusion
A stable culture of progenitor cells isolated from the dermal papilla could be established. Even after 11 passages, cells retained the ability to both form 3D spheres and express the stem cell marker Sox2, suggesting a stem cell phenotype. Using this culture we can now effectively evaluate the influence of cosmetic actives on dermal stem cells. A variety of evaluations may be made, including both molecular (i.e. stem cell marker expression) and phenotypic (i.e. number of spheres, proportion of complete spheres, serial passaging of 3D spheres etc). This approach will provide us with detailed insights into the behaviour and activity of dermal stem cells in the presence of cosmetic actives, thus enabling the evaluation of their ability to maintain or restore their regenerative potential in the dermis. Protection and vitalization of human dermal stem cells is the next generation of stem cell cosmetics. Active ingredients with these properties offer a deep-seated rejuvenation of the skin, resulting in restoration of firmness and wrinkle reduction. In addition, such products could also be beneficial in wound healing and the treatment of stretch marks.